The Central Dogma redefined

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2-min read | Biochemistry

As the old adage goes, which came first: the chicken or the egg?

In considering the Central Dogma of Molecular Biology, which follows that:
DNA > RNA > proteins, how could DNA arise before the RNA or protein that goes into its production in the cell

New research proposes that both DNA and RNA were created together on the primordial earth from progenitor molecules called diamidophosphate (DAP).

This research challenges the old hypothesis that primitive RNA molecules were the first nucleic acids on earth, which gave rise to DNA molecules within ancient lifeforms. 🥽

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Ramanarayanan Krishnamurthy, Eddy I. Jiménez, Clémentine Gibard. Prebiotic Phosphorylation and Concomitant Oligomerization of Deoxynucleosides to form DNA. Angewandte Chemie International Edition, 2020; DOI: 10.1002/anie.202015910

Scripps Research Institute. (2020, December 28). Discovery boosts theory that life on Earth arose from RNA-DNA mix: Newly described chemical reaction could have assembled DNA building blocks before life forms and their enzymes existed. ScienceDaily. Retrieved January 20, 2021 from


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